FKBP1A 抗体 (AA 43-74)
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北京 101111
Quick Overview for FKBP1A 抗体 (AA 43-74) (ABIN3030968)
抗原
See all FKBP1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 43-74
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交叉反应 (详细)
- Expected species reactivity: Mouse, Rat, Bovine, Rabbit
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纯化方法
- Purified
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免疫原
- A portion of amino acids 43-74 from the human protein was used as the immunogen for this FKBP12 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the FKBP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the FKBP12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
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别名
- FKBP12
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背景
- FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
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UniProt
- P62942
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途径
- Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
抗原
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