EZH2 抗体 (AA 260-295)
Quick Overview for EZH2 抗体 (AA 260-295) (ABIN3030807)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 260-295
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纯化方法
- Antigen affinity purified
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免疫原
- This EZH2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 260-295 amino acids of mouse Ezh2.
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亚型
- Ig Fraction
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anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibody
EZH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibodyEZH2 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibodyEZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 410-440) antibodyEZH2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2921 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人 WB 宿主: 小鼠 Monoclonal EZH2-2536 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-250) antibodyEZH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (Internal Region) antibodyEZH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the EZH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the EZH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
- Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer, involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
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UniProt
- Q61188
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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