MAPK7 抗体 (AA 776-805)
Our Local Distributor
北京 101111
Quick Overview for MAPK7 抗体 (AA 776-805) (ABIN3031834)
抗原
See all MAPK7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 776-805
-
交叉反应 (详细)
- Expected species reactivity: Mouse, Rat, Bovine
-
纯化方法
- Purified
-
免疫原
- A portion of amino acids 776-805 from the human protein was used as the immunogen for this ERK5 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the ERK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the ERK5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))
-
别名
- ERK5
-
背景
- MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
-
UniProt
- Q13164
-
途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling
抗原
-