APC 抗体 (AA 1148-1176)
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Quick Overview for APC 抗体 (AA 1148-1176) (ABIN3029869)
抗原
See all APC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1148-1176
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 1148-1176 from the human protein was used as the immunogen for this APC antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the APC antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the APC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- APC (Adenomatous Polyposis Coli (APC))
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别名
- APC
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背景
- This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
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UniProt
- P25054
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途径
- WNT signaling, Stem Cell Maintenance, Cell-Cell Junction Organization
抗原
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