FADD 抗体
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北京 101111
Quick Overview for FADD 抗体 (ABIN4953248)
抗原
See all FADD 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G affinity
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免疫原
- A human recombinant protein was used as the immunogen for this FADD antibody.
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亚型
- IgG2a
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应用备注
- The stated application concentrations are suggested starting points. Titration of the FADD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500,Immunoprecipitation: suitable
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限制
- 仅限研究用
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缓冲液
- Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300
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储存条件
- -20 °C
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储存方法
- Store the FADD antibody at -20°C.
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- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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别名
- FADD
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背景
- Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. [UniProt]
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UniProt
- Q13158
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途径
- Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
抗原
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