HSD11B2 抗体
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北京 101111
Quick Overview for HSD11B2 抗体 (ABIN4951362)
抗原
See all HSD11B2 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity
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免疫原
- Amino acids EKRKQLLLANLPQELLQAYGKDYIEHLHGQFLH of human HSD11B2 were used as the immunogen for the HSD11B2 antibody.
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亚型
- IgG
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anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 151-250) antibody
HSD11B2 适用: 小鼠, 大鼠, 马 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 1-405) antibodyHSD11B2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 277-309), (C-Term) antibodyHSD11B2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (fro), IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (N-Term) antibodyHSD11B2 适用: 人, 小鼠, 大鼠, 马, Cow, 豚鼠, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 212-343) antibodyHSD11B2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) antibodyHSD11B2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 1-405) antibodyHSD11B2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 277-306) antibodyHSD11B2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24535 unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 284-314), (Middle Region) antibodyHSD11B2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 266-405) antibodyHSD11B2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HSD11B2 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the HSD11B2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
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别名
- HSD11B2
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背景
- Corticosteroid 11-β,-dehydrogenase isozyme 2, also known as 11-β,-hydroxysteroid dehydrogenase 2, is an enzyme that in humans is encoded by the HSD11B2 gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
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UniProt
- P80365
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途径
- Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
抗原
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