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Recombinant Keratin Acidic (AE1) 抗体

The 兔 单克隆 anti-Keratin Acidic antibody is suitable to detect Keratin Acidic in samples from 人. It has been validated for IHC (p).
产品编号 ABIN4949248
发货至: 中国
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Quick Overview for Recombinant Keratin Acidic (AE1) 抗体 (ABIN4949248)

抗原

See all Keratin Acidic (AE1) 抗体
Keratin Acidic (AE1)

抗体类型

Recombinant Antibody

适用

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宿主

  • 23
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克隆类型

  • 37
单克隆

标记

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非结合性

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

KRTL-1577R
  • 原理

    Recombinant Acidic Cytokeratin Antibody / Rabbit Monoclonal (azide and preservative free)

    纯化方法

    Protein A affinity chromatography

    免疫原

    An amino acid sequence common to acidic/type I keratins (1) was used as the immunogen for the recombinant Acidic Cytokeratin antibody.

    亚型

    IgG, kappa
  • 应用备注

    Titering of the recombinant Acidic Cytokeratin antibody may be required for optimal performance.

    1. This antibody will detect cytokeratins -10, -14, -15, -16, -19.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant Acidic Cytokeratin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Keratin Acidic (AE1)

    别名

    Acidic Cytokeratin

    背景

    There are two types of cytokeratins/keratins/CKs: the acidic type I cytokeratins and the basic or neutral type II cytokeratins. The subsets of cytokeratins which an epithelial cell expresses depends mainly on the type of epithelium, the moment in the course of terminal differentiation and the stage of development. Thus this specific keratin fingerprint allows the classification of all epithelia upon their keratin expression profile. Furthermore this applies also to the malignant counterparts of the epithelia (carcinomas), as the keratin profile tends to remain constant when an epithelium undergoes malignant transformation. The main clinical implication is that the study of the keratin profile by immunohistochemistry techniques is a tool of immense value widely used for tumor diagnosis and characterization in surgical pathology. [Wiki]

    UniProt

    Q7Z794
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