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Recombinant Keratin Acidic (AE1) 抗体

This 兔 单克隆 antibody specifically detects Keratin Acidic in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN3026306
发货至: 中国
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Quick Overview for Recombinant Keratin Acidic (AE1) 抗体 (ABIN3026306)

抗原

See all Keratin Acidic (AE1) 抗体
Keratin Acidic (AE1)

抗体类型

Recombinant Antibody

适用

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宿主

  • 23
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克隆类型

  • 37
单克隆

标记

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  • 1
非结合性

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RMAK1-1
  • 原理

    Recombinant Acidic Cytokeratin Antibody / Rabbit Monoclonal

    纯化方法

    Protein A affinity chromatography

    免疫原

    An amino acid sequence common to acidic/type I keratins (1) was used as the immunogen for the recombinant Acidic Cytokeratin antibody.

    亚型

    IgG, kappa
  • 应用备注

    Titering of the recombinant Acidic Cytokeratin antibody may be required for optimal performance.

    1. This antibody will detect cytokeratins -10, -14, -15, -16, -19.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant Acidic Cytokeratin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Keratin Acidic (AE1)

    别名

    Acidic Cytokeratin

    背景

    There are two types of cytokeratins/keratins/CKs: the acidic type I cytokeratins and the basic or neutral type II cytokeratins. The subsets of cytokeratins which an epithelial cell expresses depends mainly on the type of epithelium, the moment in the course of terminal differentiation and the stage of development. Thus this specific keratin fingerprint allows the classification of all epithelia upon their keratin expression profile. Furthermore this applies also to the malignant counterparts of the epithelia (carcinomas), as the keratin profile tends to remain constant when an epithelium undergoes malignant transformation. The main clinical implication is that the study of the keratin profile by immunohistochemistry techniques is a tool of immense value widely used for tumor diagnosis and characterization in surgical pathology. [Wiki]

    UniProt

    Q7Z794
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