Endonuclease G 抗体 (AA 51-140)
Quick Overview for Endonuclease G 抗体 (AA 51-140) (ABIN492521)
抗原
See all Endonuclease G (ENDOG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 51-140
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特异性
- Recognizes Endonuclease G (EndoG)
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产品特性
- Synonyms: Endo-G, Endonuclease G mitochondrial
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纯化方法
- Immunoaffinity Chromotography.
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免疫原
- Recombinant protein corresponding to amino acids 51–140 of Human EndoG.
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亚型
- IgG
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anti-Endonuclease G (ENDOG) (AA 101-200) antibody
ENDOG 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 16-290) antibodyENDOG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 55-70) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 49-297) antibodyENDOG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 50-297) antibodyENDOG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (C-Term) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 76-170) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB 宿主: 小鼠 Monoclonal 7G1C10 unconjugated
anti-Endonuclease G (ENDOG) (AA 1-294) antibodyENDOG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 188-217), (C-Term) antibodyENDOG 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB19287 unconjugated
anti-Endonuclease G (ENDOG) (Middle Region) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: EndoG antibody can be used for detection of EndoG at 2.5-5 μg/mL. Positive Controls: HepG2 cell lysate, EndoG Recombinant Protein.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
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Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch. -
有效期
- 12 months
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- Endonuclease G (ENDOG)
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别名
- Endonuclease G
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背景
- The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro.Synonyms: ENDOG
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基因ID
- 2021
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UniProt
- Q14249
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途径
- Apoptosis
抗原
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