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p63 抗体

The 小鼠 单克隆 anti-p63 antibody is suitable to detect p63 in samples from 人. It has been validated for WB.
产品编号 ABIN4914776
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for p63 抗体 (ABIN4914776)

抗原

See all p63 (TP63) 抗体
p63 (TP63) (Tumor Protein P63 (TP63))

适用

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宿主

  • 46
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小鼠

克隆类型

  • 39
  • 31
单克隆

标记

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This p63 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

3C3
  • 交叉反应

    纯化方法

    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

    免疫原

    This TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.

    亚型

    IgM
  • 应用备注

    WB 1:300-5000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    p63 (TP63) (Tumor Protein P63 (TP63))

    别名

    TP63

    背景

    Synonyms: AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), Tumor protein 63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like

    Background: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

    基因ID

    8626

    UniProt

    Q9H3D4
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