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RAD50 抗体 (AA 817-872) (Biotin)

This anti-RAD50 antibody is a 兔 多克隆 antibody detecting RAD50 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人 和 小鼠.
产品编号 ABIN4913429
发货至: 中国

Quick Overview for RAD50 抗体 (AA 817-872) (Biotin) (ABIN4913429)

抗原

See all RAD50 抗体
RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This RAD50 antibody is conjugated to Biotin

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 817-872

    交叉反应

    人, 小鼠

    预测反应

    Rat,Cow,Sheep,Horse,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human RAD50

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

    别名

    RAD50

    背景

    Synonyms: DNA repair protein RAD50, RAD50, hRAD50

    Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

    基因ID

    10111

    UniProt

    Q92878

    途径

    DNA Damage Repair, Protein targeting to Nucleus
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