PDK4 抗体
Our Local Distributor
北京 101111
Quick Overview for PDK4 抗体 (ABIN4912899)
抗原
See all PDK4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人
-
纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
-
免疫原
- Purified His-tagged PDK4 protein(Fragment) was used to produced this monoclonal antibody.
-
亚型
- IgG1
-
-
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 382-410), (C-Term) antibody
PDK4 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB03041 unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 117-387) antibodyPDK4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 382-410) antibodyPDK4 适用: 人, 小鼠 WB, IHC, ELISA, IF, mIHC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 102-411) antibodyPDK4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 83-111) antibodyPDK4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 1-411) antibodyPDK4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (N-Term) antibodyPDK4 适用: 人, 小鼠, 大鼠, 马, Pig, 兔, Cow, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 143-333) antibodyPDK4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 1-411) antibodyPDK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (C-Term) antibodyPDK4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:300-5000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C for 12 months.
-
有效期
- 12 months
-
-
- PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
-
别名
- PDK4
-
背景
-
Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4, PDK4, PDHK4
Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
-
基因ID
- 5166
-
UniProt
- Q16654
-
途径
- PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
-
