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c-Rel 抗体

c-Rel 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 8C2 unconjugated
产品编号 ABIN4906804
发货至: 中国
  • 抗原 See all c-Rel 抗体
    c-Rel (REL proto-oncogene (c-Rel))
    适用
    • 84
    • 24
    • 6
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    • 5
    • 4
    • 4
    • 4
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    • 2
    • 1
    • 1
    宿主
    • 79
    • 8
    • 1
    小鼠
    克隆类型
    • 72
    • 16
    单克隆
    标记
    • 36
    • 9
    • 4
    • 4
    • 4
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    This c-Rel antibody is un-conjugated
    应用范围
    • 60
    • 38
    • 13
    • 13
    • 10
    • 9
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    纯化方法
    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
    免疫原
    This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
    克隆位点
    8C2
    亚型
    IgG2b
    Top Product
    Discover our top product c-Rel Primary Antibody
  • 应用备注
    WB 1:300-5000
    IF()
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    c-Rel (REL proto-oncogene (c-Rel))
    别名
    C-rel (c-Rel 产品)
    别名
    C-Rel antibody, c-Rel antibody, NFkB antibody, c-rel antibody, zgc:100833 antibody, Xrel2 antibody, Xrel3 antibody, rel antibody, rel-A antibody, rel2 antibody, rel3 antibody, v-rel antibody, xrel antibody, REL proto-oncogene, NF-kB subunit antibody, reticuloendotheliosis oncogene antibody, RELA proto-oncogene, NF-kB subunit antibody, v-rel avian reticuloendotheliosis viral oncogene homolog antibody, v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog antibody, ribonuclease A family member 2 pseudogene antibody, REL antibody, Rel antibody, Rela antibody, rel antibody, rel.L antibody, ECRP antibody
    背景

    Synonyms: C-Rel, Proto-oncogene c-Rel, REL

    Background: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

    基因ID
    5966
    UniProt
    Q04864
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