Immunohistochemistry on Paraffin Sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
1.0 mg/mL
缓冲液
PBS containing 0.09 % Sodium Azide as preservative.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.
Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and the Duffy blood group antigen. The C - C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. CCR4 mediates inflammatory responses and HIV-1 infections. It binds beta-family chemokines (CC motif) such as TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derived chemokine).Synonyms: C-C CKR-4, C-C chemokine receptor type 4, CC-CKR-4, CCR-4, CMKBR4, K5-5