MAPT 抗体 (Ser214)
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北京 101111
Quick Overview for MAPT 抗体 (Ser214) (ABIN401618)
抗原
See all MAPT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Ser214
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特异性
- Tau Antibody detects endogenous levels of total Tau protein.
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纯化方法
- Affinity chromatography
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免疫原
- Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 214 (T-P-SP-L-P)
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anti-Microtubule-Associated Protein tau (MAPT) (AA 1-100) antibody
MAPT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer262) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr212) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer235) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (AA 130-386) antibodyMAPT 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (AA 34-368) antibodyMAPT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr181) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pThr205) antibodyMAPT 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer396) antibodyMAPT 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Microtubule-Associated Protein tau (MAPT) (pSer404) antibodyMAPT 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunofluorescence: 1/100 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- MAPT (Microtubule-Associated Protein tau (MAPT))
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别名
- MAPT / tau
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背景
- Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
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基因ID
- 4137
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NCBI登录号
- NP_001116538
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UniProt
- P10636
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途径
- MAPK Pathway, Microtubule Dynamics, M Phase, Regulation of Cell Size
抗原
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