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EGFR 抗体 (AA 1189-1199)

This anti-EGFR antibody is a 兔 多克隆 antibody detecting EGFR in WB 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN401323
发货至: 中国

Quick Overview for EGFR 抗体 (AA 1189-1199) (ABIN401323)

抗原

See all EGFR 抗体
EGFR (Epidermal Growth Factor Receptor (EGFR))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This EGFR antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    AA 1189-1199

    特异性

    This antibody is directed against epidermal growth factor receptor (EGFR)

    纯化方法

    Affinity chromatography

    免疫原

    Synthetic peptide corresponding to amino acids 1189-1199 of human EGFR protein

    亚型

    IgG
  • 应用备注

    ELISA: 1/8,000 - 1/32,000. Western Blot 1/500 - 1/5,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL (by UV absorbance at 280 nm)

    缓冲液

    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C
  • 抗原

    EGFR (Epidermal Growth Factor Receptor (EGFR))

    别名

    EGFR / ERBB1

    背景

    EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. For example, the epidermal growth factor receptor (EGFR) is mutated and/or overexpressed in many common solid human squamous cell carcinomas including breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. Overexpression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and erbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB-4/HER-4neu. EGFR can heterodimerize with each of the members of this family.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1

    基因ID

    1956

    NCBI登录号

    NP_005219

    UniProt

    P00533

    途径

    NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
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