MARK2 抗体 (Isoform A, pThr595)
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Quick Overview for MARK2 抗体 (Isoform A, pThr595) (ABIN401318)
抗原
See all MARK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Isoform A, pThr595
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特异性
- This antibody is directed against the phosphorylated form of MARK2 at thepT595 residue.
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交叉反应 (详细)
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Species reactivity (expected):Canine, Bovine, Mouse, Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to amino acids surrounding T595 of Human MARK2 isoform a. The immunogen peptide was phosphorylated at the residue corresponding to T595
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亚型
- IgG
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应用备注
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ELISA: 1/1,000 - 1/3,000. Western Blot: 1/250 - 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.6 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
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别名
- MARK2
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背景
- This antibody recognizes a regulatory phosphorylation on a kinase that is critical to regulation of microtubules, cell cycle and immune responses. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gives rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be co-expressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA that is ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.Synonyms: 2, ELKL motif kinase, EMK1, MAP/microtubule affinity-regulating kinase, MARK2, PAR1 homolog, Serine/threonine-protein kinase
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基因ID
- 2011
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NCBI登录号
- NP_001034558
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UniProt
- Q7KZI7
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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