ULK2 抗体 (C-Term)
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Quick Overview for ULK2 抗体 (C-Term) (ABIN392693)
抗原
See all ULK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 612-643, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-643 amino acids from the C-terminal region of human ULK2.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- ULK2 (Unc-51 Like Kinase 2 (ULK2))
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别名
- ULK2
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背景
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
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分子量
- 112694
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基因ID
- 9706
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NCBI登录号
- NP_001136082, NP_055498
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UniProt
- Q8IYT8
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途径
- Regulation of Cell Size, Autophagy
抗原
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