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PAK3 抗体 (AA 218-247)

This 兔 多克隆 anti-PAK3 antibody (Clone RB1223-1224) specifically detects PAK3 in WB 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN392435
发货至: 中国
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Quick Overview for PAK3 抗体 (AA 218-247) (ABIN392435)

抗原

See all PAK3 抗体
PAK3

适用

  • 85
  • 41
  • 30
  • 3

宿主

  • 80
  • 5
  • 2

克隆类型

  • 70
  • 18
多克隆

标记

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This PAK3 antibody is un-conjugated

应用范围

  • 68
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB1223-1224
  • 抗原表位

    • 17
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    AA 218-247

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This PAK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human PAK3.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    PAK3

    别名

    PAK3

    背景

    PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30). The protein structure contains 1 CRIB domain.

    分子量

    62310

    基因ID

    5063

    NCBI登录号

    NP_001121638, NP_001121639, NP_001121640, NP_001121644, NP_001121645, NP_002569

    UniProt

    O75914
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