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RYK 抗体 (AA 160-190)

This anti-RYK antibody is a 兔 多克隆 antibody detecting RYK in WB 和 IHC (p). Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN392050
发货至: 中国

Quick Overview for RYK 抗体 (AA 160-190) (ABIN392050)

抗原

See all RYK 抗体
RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

适用

人, 小鼠, 大鼠

宿主

  • 44
  • 12
  • 3
  • 1

克隆类型

  • 49
  • 11
多克隆

标记

  • 37
  • 5
  • 5
  • 5
  • 4
  • 4
This RYK antibody is un-conjugated

应用范围

  • 54
  • 41
  • 27
  • 7
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB1491
  • 抗原表位

    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 160-190

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This RYK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from human RYK.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze-thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

    有效期

    6 months
  • Povinelli, Nemeth: "Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor." in: Stem cells (Dayton, Ohio), Vol. 32, Issue 1, pp. 105-15, (2014) (PubMed).

    González, Fernández-Martos, Arenas, Rodríguez: "The Ryk receptor is expressed in glial and fibronectin-expressing cells after spinal cord injury." in: Journal of neurotrauma, Vol. 30, Issue 10, pp. 806-17, (2013) (PubMed).

    Santiago, Oguma, Brown, Laurence: "Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 223-30, (2012) (PubMed).

    Miyashita, Koda, Kitajo, Yamazaki, Takahashi, Kikuchi, Yamashita: "Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury." in: Journal of neurotrauma, Vol. 26, Issue 7, pp. 955-64, (2009) (PubMed).

  • 抗原

    RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

    别名

    RYK

    背景

    RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.

    分子量

    67815

    基因ID

    6259

    NCBI登录号

    NP_001005861, NP_002949

    UniProt

    P34925

    途径

    RTK signaling, WNT signaling, Regulation of Cell Size
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