Insulin Receptor 抗体 (N-Term)
Quick Overview for Insulin Receptor 抗体 (N-Term) (ABIN2841788)
抗原
See all Insulin Receptor (INSR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 27-57, N-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Insulin Receptor R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-57 amino acids from the N-terminal region of human Insulin Receptor R.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. WB: 1:2000. WB: 1:2000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- Insulin Receptor (INSR)
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别名
- Insulin Receptor R
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背景
- Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
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分子量
- 143720
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基因ID
- 3645
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NCBI登录号
- NP_055030
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UniProt
- P14616
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途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
抗原
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