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RIPK3 抗体 (N-Term)

Cited in 2+ publications. This 兔 多克隆 anti-RIPK3 antibody (Clone RB8631) specifically detects RIPK3 in WB 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN391272
发货至: 中国
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Quick Overview for RIPK3 抗体 (N-Term) (ABIN391272)

抗原

See all RIPK3 抗体
RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

适用

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宿主

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克隆类型

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多克隆

标记

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This RIPK3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB8631
  • 抗原表位

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    AA 1-30, N-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RIPK3.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Viringipurampeer, Metcalfe, Bashar, Sivak, Yanai, Mohammadi, Moritz, Gregory-Evans, Gregory-Evans: "NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration." in: Human molecular genetics, Vol. 25, Issue 8, pp. 1501-16, (2016) (PubMed).

    Viringipurampeer, Ferreira, DeMaria, Yoon, Shan, Moosajee, Gregory-Evans, Ngai, Gregory-Evans: "Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2357-69, (2012) (PubMed).

  • 抗原

    RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

    别名

    RIPK3

    背景

    The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

    分子量

    56887

    基因ID

    11035

    NCBI登录号

    NP_006862

    UniProt

    Q9Y572

    途径

    Activation of Innate immune Response, Toll-Like Receptors Cascades
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