我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

PDK2 抗体 (C-Term)

Name: PDK2 抗体 (C-Term)
SKU: ABIN391037
Availability: OutOfStock

This anti-PDK2 antibody is a 兔多克隆 antibody detecting PDK2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 10+ publications.

Western blot analysis of PDK2 (arrow) using PDK2 Antibody (C-term) (ABIN391037 and ABIN2841203). (PDK2 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (PDK2 抗体 (C-Term))

IHC (p)

2 images

(10 references)

产品编号 ABIN391037

发货至: 中国

Quick Overview for PDK2 抗体 (C-Term) (ABIN391037)

抗原

See all PDK2 抗体

PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PDK2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB03037

Discover our top product PDK2 Primary Antibody

抗原表位
15

9

8

6

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 378-407, C-Term

预测反应

M, Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This PDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-407 amino acids from the C-terminal region of human PDK2.

亚型

Ig Fraction
anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 187-276) antibody
PDK2 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2G1 unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 155-379) antibody
PDK2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 178-404) antibody
PDK2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3F2D7 unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (C-Term) antibody
PDK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 128-407) antibody
PDK2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 128-407) antibody
PDK2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 379-392), (C-Term) antibody
PDK2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) (AA 78-107), (N-Term) antibody
PDK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB34663 unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) antibody
PDK2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23089 unconjugated

anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) antibody
PDK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 7E5 unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Hurd, Collins, Abakumova, Chouchani, Baranowski, Fearnley, Prime, Murphy, James: "Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35153-60, (2012) (PubMed).

Love, LeBlanc, Inglis, Bradley, Choptiany, Heigenhauser, Peters: "The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 111, Issue 2, pp. 427-34, (2011) (PubMed).

Dunford, Herbst, Jeoung, Gittings, Inglis, Vandenboom, LeBlanc, Harris, Peters: "PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 6, pp. R1487-93, (2011) (PubMed).

Nicholls, Chu, Abbruzzese, Tremblay, Hardy: "Mechanism of a genetically encoded dark-to-bright reporter for caspase activity." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24977-86, (2011) (PubMed).

McClenaghan, Scullion, Mion, Hewage, Malthouse, Flatt, Newsholme, Brennan: "Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells." in: Clinical science (London, England : 1979), Vol. 116, Issue 4, pp. 341-51, (2009) (PubMed).

Sun, Zhou, Chang, McFate, Verma, Califano: "Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 476-84, (2009) (PubMed).

Richards, Sardella, Schulte: "Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 295, Issue 3, pp. R979-90, (2008) (PubMed).

Zhang, Ma, Sadana, Chowdhury, Gaillard, Wang, McDonnell, Unterman, Elam, Park: "Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression." in: The Journal of biological chemistry, Vol. 281, Issue 52, pp. 39897-906, (2006) (PubMed).

Xu, Han, Epstein, Liu: "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 827-33, (2006) (PubMed).

Churchill, Murriel, Chen, Mochly-Rosen, Szweda: "Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation." in: Circulation research, Vol. 97, Issue 1, pp. 78-85, (2005) (PubMed).
抗原

PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

别名

PDK2

背景

PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

分子量

46154

基因ID

5164

NCBI登录号

NP_001186827, NP_001186828, NP_002602

UniProt

Q15119

途径

PI3K-Akt Signaling, RTK signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect