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Presenilin 1 抗体 (C-Term)

Name: Presenilin 1 抗体 (C-Term)
SKU: ABIN390169
Availability: OutOfStock

Cited in 1 publication. This anti-Presenilin 1 antibody is a 兔多克隆 antibody detecting Presenilin 1 in WB, IHC (p), FACS 和 IF. Suitable for 人和小鼠.

All lanes : Anti-PSEN1 Antibody (C-term) at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 μg per lane. (Presenilin 1 抗体 (C-Term))

Presenilin 1 (PSEN1) Antibody (C-term) (ABIN390169 and ABIN2840665) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). (Presenilin 1 抗体 (C-Term))

FACS

Confocal immunofluorescent analysis of Presenilin 1 (PSEN1) Antibody (C-term) (ABIN390169 and ABIN2840665) with MDA-M cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Presenilin 1 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Presenilin 1 抗体 (C-Term))

IHC (p)

4 images

(1 reference)

产品编号 ABIN390169

发货至: 中国

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中国
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Quick Overview for Presenilin 1 抗体 (C-Term) (ABIN390169)

抗原

See all Presenilin 1 (PSEN1) 抗体

Presenilin 1 (PSEN1)

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This Presenilin 1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

RB2257

Discover our top product PSEN1 Primary Antibody

抗原表位
31

15

15

9

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3

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2

2

2

2

1

1

1

1

1

1

1

1

1

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1

1

1

1

1

1

1

1

1

1

1

1

1
AA 330-359, C-Term

预测反应

Pr, Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1).

亚型

Ig Fraction
anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (pSer310) antibody
KD Validated PSEN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4510 unconjugated Recombinant Antibody

anti-Presenilin 1 (PSEN1) (AA 4-218) antibody
PSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (Middle Region) antibody
PSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 300-349) antibody
PSEN1 适用: 人, 小鼠, 猴, Cow, Pig, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 107-156) antibody
PSEN1 适用: 人, 小鼠, 大鼠, 猴, Pig, 豚鼠, 犬, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (N-Term) antibody
PSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 10-80) antibody
PSEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 10-80) antibody
PSEN1 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 小鼠 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
抗原

Presenilin 1 (PSEN1)

背景

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

分子量

52668

基因ID

5663

NCBI登录号

NP_000012, NP_015557

UniProt

P49768

途径

Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport