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SYK 抗体 (pTyr525, pTyr526)

Cited in 5+ publications. The 兔多克隆 anti-SYK antibody (Clone RB5669) (ABIN389670) specifically detects SYK in WB 和 IHC (p). The antibody is reactive with 人 samples.

Western blot analysis of lysates from Raji cell line, untreated or treated with T, 200nM, 30 min, using 457167101 (ABIN389670 and ABIN2850453) (upper) or Tubulin (lower). (SYK 抗体 (pTyr525, pTyr526))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (SYK 抗体 (pTyr525, pTyr526))

IHC (p)

2 images

(5 references)

产品编号 ABIN389670

发货至: 中国

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Quick Overview for SYK 抗体 (pTyr525, pTyr526) (ABIN389670)

抗原

See all SYK 抗体

SYK (Spleen tyrosine Kinase (SYK))

适用

人

宿主

兔

克隆类型

多克隆

标记

This SYK antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB5669

Discover our top product SYK Primary Antibody

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pTyr525, pTyr526

预测反应

M, Pig, Rat

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Syk Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y525/526 of human Syk.

亚型

IgG
anti-Spleen tyrosine Kinase (SYK) (AA 5-360) antibody
SYK 适用: 人, 小鼠, 大鼠 WB, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal SYK-01 unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr323) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr348) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr525) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (Internal Region) antibody
SYK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 217-356) antibody
SYK 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3D1G10 unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 217-356) antibody
SYK 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2G11E6 unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 387-417), (C-Term) antibody
SYK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03097 unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 10-635) antibody
SYK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr525), (pTyr526) antibody
SYK 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:250. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Schweig, Yao, Beaulieu-Abdelahad, Ait-Ghezala, Mouzon, Crawford, Mullan, Paris: "Alzheimer's disease pathological lesions activate the spleen tyrosine kinase." in: Acta neuropathologica communications, Vol. 5, Issue 1, pp. 69, (2018) (PubMed).

Köhler, Fuhr, Dinekov: "Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus." in: Brain research, Vol. 1677, pp. 1-13, (2018) (PubMed).

Greenblatt, Park, Oh, Kim, Shin, Lee, Lee, Singh, Lee, Hu, Xiao, Charles, Penninger, Lotinun, Baron, Ghosh, Shim: "CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts." in: The Journal of experimental medicine, Vol. 212, Issue 8, pp. 1283-301, (2015) (PubMed).

Nishikawa, Takahashi, Nakamori, Hosomi, Maruyama, Miyazaki, Izumi, Matsumoto: "The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments." in: Neuropathology and applied neurobiology, (2015) (PubMed).

Satoh, Tabunoki, Ishida, Yagishita, Jinnai, Futamura, Kobayashi, Toyoshima, Yoshioka, Enomoto, Arai, Saito, Arima: "Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 2, pp. 149-57, (2012) (PubMed).
抗原

SYK (Spleen tyrosine Kinase (SYK))

别名

Syk

背景

Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.

分子量

72066

基因ID

6850

NCBI登录号

NP_001128524, NP_001167638, NP_001167639, NP_003168

UniProt

P43405

途径

Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling