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Ubiquilin 1 抗体 (AA 296-326)

Name: Ubiquilin 1 抗体 (AA 296-326)
SKU: ABIN388966
Availability: OutOfStock

This anti-Ubiquilin 1 antibody is a 兔多克隆 antibody detecting Ubiquilin 1 in WB, IHC (p) 和 IF. Suitable for 人和小鼠. This Primary Antibody has been cited in 3+ publications.

Ubiquilin1 Antibody (ABIN388966 and ABIN2837881) western blot analysis in SH-SY5Y cell line lysates (35 μg/lane). (Ubiquilin 1 抗体 (AA 296-326))

Immunofluorescent analysis of Hela cells, using Ubiquilin1 Antibody (Center) (ABIN388966 and ABIN2837881). (Ubiquilin 1 抗体 (AA 296-326))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (Ubiquilin 1 抗体 (AA 296-326))

IHC (p)

3 images

(3 references)

产品编号 ABIN388966

发货至: 中国

Quick Overview for Ubiquilin 1 抗体 (AA 296-326) (ABIN388966)

抗原

See all Ubiquilin 1 (UBQLN1) 抗体

Ubiquilin 1 (UBQLN1)

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This Ubiquilin 1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

克隆位点

RB4554

Discover our top product UBQLN1 Primary Antibody

抗原表位
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AA 296-326

预测反应

Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Ubiquilin1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-326 amino acids from the Central region of human Ubiquilin1.

亚型

Ig Fraction
anti-Ubiquilin 1 (UBQLN1) (AA 290-339) antibody
UBQLN1 适用: 人, Cow, 犬, 豚鼠, 马, 兔, 绵羊, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 296-326) antibody
UBQLN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 1-300) antibody
UBQLN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibody
UBQLN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C6-A3 unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibody
UBQLN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C6-B7 unconjugated

anti-Ubiquilin 1 (UBQLN1) (Internal Region) antibody
UBQLN1 适用: 人 WB, ELISA, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal 3D5E2 unconjugated

anti-Ubiquilin 1 (UBQLN1) antibody
UBQLN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 19-49), (N-Term) antibody
UBQLN1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4615 unconjugated

anti-Ubiquilin 1 (UBQLN1) (AA 40-70) antibody
UBQLN1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Ubiquilin 1 (UBQLN1) antibody
UBQLN1 适用: 人, 小鼠 WB, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:100. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Chen, Wang, Jiang, Zheng, Justice, Wang, Ran, Li, Huo, Zhang, Li, Lu, Wang, Zheng, Long, Yang: "APP modulates KCC2 expression and function in hippocampal GABAergic inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Bieniek, Murray, Rutherford, Castanedes-Casey, DeJesus-Hernandez, Liesinger, Baker, Boylan, Rademakers, Dickson: "Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion." in: Acta neuropathologica, Vol. 125, Issue 2, pp. 289-302, (2013) (PubMed).

Bao, Zhang, Zheng, Xu, Yan: "UBQLN1 interacts with SPEM1 and participates in spermiogenesis." in: Molecular and cellular endocrinology, Vol. 327, Issue 1-2, pp. 89-97, (2010) (PubMed).
抗原

Ubiquilin 1 (UBQLN1)

别名

Ubiquilin1

背景

Ubiquilin 1 (UBQLN1), also known as DA41, was isolated from an adult rat lung cDNA library, and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes. The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN. Human DA41 encodes a 589-amino acid protein with 86 % amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner. PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein. PLIC1, also called UBQLN1, shares 72 % amino acid identity with PLIC2,3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain. Unlike ubiquitin, the UBL domain of the PLICs does not have a diglycine motif in its C terminus. The UBA domain is present in multiple enzyme classes of the ubiquitination machinery. Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes. Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates, p53 and I-kappa-B-alpha (NFKBIA), but not a ubiquitin-independent substrate. PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The DA41 gene maps to chromosome 9q21.2-q21.3, a position overlapping a candidate tumor suppressor locus for bladder cancer.2

分子量

62519

基因ID

29979

NCBI登录号

NP_038466, NP_444295

UniProt

Q9UMX0