Ubiquilin 1 抗体 (AA 1-300)
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- 抗原 See all Ubiquilin 1 (UBQLN1) 抗体
- Ubiquilin 1 (UBQLN1)
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抗原表位
- AA 1-300
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Ubiquilin 1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Ubiquilin-1 protein (1-300AA)
- 亚型
- IgG
- Top Product
- Discover our top product UBQLN1 Primary Antibody
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anti-Ubiquilin 1 (UBQLN1) (AA 290-339) antibody
UBQLN1 适用: 人, 马, 兔, 绵羊, Cow, 犬, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 296-326) antibodyUBQLN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibodyUBQLN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C6-B7 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibodyUBQLN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C6-A3 unconjugated
anti-Ubiquilin 1 (UBQLN1) (Internal Region) antibodyUBQLN1 适用: 人 WB, ELISA, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal 3D5E2 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 296-326) antibodyUBQLN1 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB4554 unconjugated
anti-Ubiquilin 1 (UBQLN1) (N-Term) antibodyUBQLN1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) antibodyUBQLN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 19-49), (N-Term) antibodyUBQLN1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4615 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 40-70) antibodyUBQLN1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Ubiquilin 1 (UBQLN1)
- 别名
- UBQLN1 (UBQLN1 产品)
- 别名
- UBQLN1 antibody, DA41 antibody, DSK2 antibody, PLIC-1 antibody, UBQN antibody, XDRP1 antibody, 1110046H03Rik antibody, 1810030E05Rik antibody, AU019746 antibody, C77538 antibody, D13Ertd372e antibody, Da41 antibody, Dsk2 antibody, Plic-1 antibody, Plic1 antibody, Xdrp1 antibody, ubiquilin 1 antibody, UBQLN1 antibody, Ubqln1 antibody
- 背景
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Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).
Aliases: DA41 antibody, DSK2 antibody, FLJ90054 antibody, hPLIC-1 antibody, hPLIC1 antibody, PLIC-1 antibody, PLIC1 antibody, Protein linking IAP with cytoskeleton 1 antibody, Ubiquilin-1 antibody, Ubiquilin1 antibody, UBQL1_HUMAN antibody, UBQLN1 antibody, UBQN antibody, XDRP1 antibody
- UniProt
- Q9UMX0
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