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Beclin 1 抗体 (AA 181-210)

Name: Beclin 1 抗体 (AA 181-210)
SKU: ABIN388545
Availability: OutOfStock

This anti-Beclin 1 antibody is a 兔多克隆 antibody detecting Beclin 1 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of anti-hBECN1- Pab (ABIN388545 and ABIN2849691) in 293 cell line lysates transiently transfected with the BECN1 gene (2 μg/lane). (Beclin 1 抗体 (AA 181-210))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Beclin 1 抗体 (AA 181-210))

IHC (p)

The anti-BECN1 Pab (ABIN388545 and ABIN2849691) is used in Western blot to detect BECN1 in mouse liver tissue lysate. (Beclin 1 抗体 (AA 181-210))

3 images

(5 references)

产品编号 ABIN388545

发货至: 中国

Quick Overview for Beclin 1 抗体 (AA 181-210) (ABIN388545)

抗原

See all Beclin 1 (BECN1) 抗体

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This Beclin 1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB7461

Discover our top product BECN1 Primary Antibody

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AA 181-210

预测反应

B, C

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from human Beclin 1.

亚型

Ig Fraction
anti-Beclin 1, Autophagy Related (BECN1) (AA 201-330) antibody
BECN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 1-354) antibody
BECN1 适用: 人, 小鼠, 大鼠 WB, IF, FACS, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB7463 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 1-273) antibody
BECN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (C-Term) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Li, Zhou, Yang, Li, Zhang, Zheng: "Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells." in: Oncology reports, Vol. 37, Issue 6, pp. 3459-3466, (2018) (PubMed).

Zhang, Yi, Ko, Kim, Seo, Lee, Lee, Kim: "Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain." in: Brain research, Vol. 1519, pp. 31-9, (2013) (PubMed).

Liu, He, von Rütte, Yousefi, Hunger, Simon: "Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma." in: Science translational medicine, Vol. 5, Issue 202, pp. 202ra123, (2013) (PubMed).

Thyagarajan, Jedinak, Nguyen, Terry, Baldridge, Jiang, Sliva: "Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)." in: Nutrition and cancer, Vol. 62, Issue 5, pp. 630-40, (2010) (PubMed).

Bohensky, Leshinsky, Srinivas, Shapiro: "Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 4, pp. 633-42, (2010) (PubMed).
抗原

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

别名

Beclin 1

背景

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.

分子量

51896

基因ID

8678

NCBI登录号

NP_003757

UniProt

Q14457

途径

Autophagy