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BNIP3 抗体 (AA 215-252)

This 兔 多克隆 antibody specifically detects BNIP3 in IF 和 IHC (p). It exhibits reactivity toward 人 和 小鼠. It has been mentioned in 3+ publications
产品编号 ABIN388117
发货至: 中国
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Quick Overview for BNIP3 抗体 (AA 215-252) (ABIN388117)

抗原

See all BNIP3 抗体
BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))

适用

  • 108
  • 58
  • 43
人, 小鼠

宿主

  • 95
  • 9
  • 7

克隆类型

  • 74
  • 37
多克隆

标记

  • 37
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This BNIP3 antibody is un-conjugated

应用范围

  • 67
  • 29
  • 26
  • 26
  • 23
  • 18
  • 13
  • 8
  • 8
  • 5
  • 4
  • 3
  • 1
  • 1
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB3385
  • 抗原表位

    • 15
    • 15
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 215-252

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This BNIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-252 amino acids from human BNIP3.

    亚型

    Ig Fraction
  • 应用备注

    IF: 1:500. IF: 1:50~100. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze-thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

    有效期

    6 months
  • Karpathiou, Sivridis, Koukourakis, Mikroulis, Bouros, Froudarakis, Bougioukas, Maltezos, Giatromanolaki: "Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 121, Issue 7, pp. 592-604, (2013) (PubMed).

    Wojtkowiak, Rothberg, Kumar, Schramm, Haller, Proemsey, Lloyd, Sloane, Gillies: "Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments." in: Cancer research, Vol. 72, Issue 16, pp. 3938-47, (2012) (PubMed).

    Metukuri, Beer-Stolz, Namas, Dhupar, Torres, Loughran, Jefferson, Tsung, Billiar, Vodovotz, Zamora: "Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 296, Issue 3, pp. G499-509, (2009) (PubMed).

  • 抗原

    BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))

    别名

    BNIP3 (NIP3)

    背景

    NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

    分子量

    27832

    基因ID

    664

    NCBI登录号

    NP_004043

    UniProt

    Q12983

    途径

    Autophagy, Brown Fat Cell Differentiation
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