(1 reference)-
- 抗原 See all SIGLEC8 抗体
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This SIGLEC8 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody reacts to SIGLEC8.
- 纯化方法
- Affinity chromatography
- 免疫原
- Peptide with sequence C-SYKSQLNYKTKQ, from the internal region of the protein sequence
- Top Product
- Discover our top product SIGLEC8 Primary Antibody
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anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 18-121) antibody
SIGLEC8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 18-121) antibodySIGLEC8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (Internal Region) antibodySIGLEC8 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 70-336) antibodySIGLEC8 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) antibodySIGLEC8 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (Extracellular Domain) antibodySIGLEC8 适用: 人 ELISA, IP, FACS 宿主: 小鼠 Monoclonal 7C9 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (Internal Region) antibodyVerified SIGLEC8 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (Extracellular Domain) antibody (PE)SIGLEC8 适用: 人 FACS 宿主: 小鼠 Monoclonal 7C9 PE
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 17-363) antibodySIGLEC8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 70-336) antibodySIGLEC8 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0,5 mg/mL
- 缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).
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: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).
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- 抗原
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
- 别名
- CD329 / SIGLEC8 (SIGLEC8 产品)
- 背景
- SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.Synonyms: CDw329, SAF2, Sialic acid-binding Ig-like lectin 8, Sialoadhesin family member 2, Siglec-8
- 基因ID
- 27181, 9606
- UniProt
- Q9NYZ4
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