TIA1 抗体 (Internal Region)
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Quick Overview for TIA1 抗体 (Internal Region) (ABIN374795)
抗原
See all TIA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-PKSTYESNTK Q
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特异性
- This antibody detects TIA1.
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交叉反应 （详细）
- Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human
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纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from the internal region of the protein sequence according to NP_071320.1, NP_071505.1 Genename: TIA1
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anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) antibody
TIA1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (AA 1-215) antibodyTIA1 适用: 人 IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3A3B9 unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) antibodyTIA1 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (AA 1-193) antibodyTIA1 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) antibodyKD Validated TIA1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2175 unconjugated Recombinant Antibody
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (AA 1-215) antibodyTIA1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2A10B12 unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) antibodyTIA1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (Internal Region) antibodyVerified TIA1 适用: 人 WB, IF, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (C-Term) antibodyTIA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (Internal Region) antibodyTIA1 适用: 人, 小鼠, 大鼠 WB, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Peptide ELISA: antibody detection limit dilution 1: 128000. Western blot: 0.1-0.3 μg/mL. Approx 40 kDa band observed in lysates of cell line Jurkat
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限制
- 仅限研究用
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
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别名
- TIA1
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背景
- TIA1 is a member of an RNA binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkin's etc. Studies showed that 60 to 70 % of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemia's, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The author's concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkin's and lymphoblastic leukemias were negative for TIA-1.Synonyms: Nucleolysin TIA-1, RNA-binding protein TIA-1, TIA1 cytotoxic granule-associated RNA binding protein, p15-TIA-1, p40-TIA-1
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基因ID
- 7072, 9606
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UniProt
- P31483
抗原
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