ALOX5 抗体 (C-Term)
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Quick Overview for ALOX5 抗体 (C-Term) (ABIN374732)
抗原
See all ALOX5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to Arachidonate 5-lipoxygenase.
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human, Rat. -
纯化方法
- Affinity chromatography
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免疫原
- Peptide with sequence C-ERNKKKQLPYYYLSPD, from the C Terminus of the protein sequence Genename: ALOX5
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应用备注
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Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
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别名
- ALOX5 / LOG5
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背景
- The enzyme 5 Lipoxygenase (5 LO) plays a key role in regulating the production of leukotrienes (LTs). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5 LO is regulated by PKA phosphorylation of serine 523 in 5 LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.Synonyms: 5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase
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基因ID
- 240, 9606
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UniProt
- P09917
抗原
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