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ALOX5 抗体 (C-Term)

The 山羊 多克隆 anti-ALOX5 antibody is suitable to detect ALOX5 in samples from 人, 小鼠, 大鼠 和 犬. It has been validated for WB.
产品编号 ABIN374732
发货至: 中国
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Quick Overview for ALOX5 抗体 (C-Term) (ABIN374732)

抗原

See all ALOX5 抗体
ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

适用

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人, 小鼠, 大鼠, 犬

宿主

  • 118
  • 10
  • 1
山羊

克隆类型

  • 107
  • 22
多克隆

标记

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This ALOX5 antibody is un-conjugated

应用范围

  • 77
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Western Blotting (WB)
  • 抗原表位

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    • 5
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    C-Term

    特异性

    This antibody reacts to Arachidonate 5-lipoxygenase.

    交叉反应 (详细)

    Species reactivity (expected):Mouse, Canine.
    Species reactivity (tested):Human, Rat.

    纯化方法

    Affinity chromatography

    免疫原

    Peptide with sequence C-ERNKKKQLPYYYLSPD, from the C Terminus of the protein sequence Genename: ALOX5
  • 应用备注

    Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

    别名

    ALOX5 / LOG5

    背景

    The enzyme 5 Lipoxygenase (5 LO) plays a key role in regulating the production of leukotrienes (LTs). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5 LO is regulated by PKA phosphorylation of serine 523 in 5 LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.Synonyms: 5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase

    基因ID

    240, 9606

    UniProt

    P09917
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