Caspase 4 抗体 (Internal Region)
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Quick Overview for Caspase 4 抗体 (Internal Region) (ABIN374466)
抗原
See all Caspase 4 (CASP4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- CKERAEEIYP IKERN
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特异性
- This antibody is expected to recognise both isoforms of CASP4 (alpha, represented by NP_001216.1 and gamma, NP-150649.1).
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Ammonium sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- Peptide from the internal region of the protein sequence according to NP_001216.1, NP_150649.1.
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anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 1-377) antibody
CASP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7G7 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 290-377) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 82-226) antibodyCASP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibodyCASP4 适用: 小鼠, 大鼠 WB, ELISA, IP, FACS 宿主: 大鼠 Monoclonal 8A5 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (cleaved), (Internal Region) antibodyCASP4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 78-265) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 81-270) antibodyCASP4 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Internal Region) antibodyVerified CASP4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 111-194) antibodyCASP4 适用: 人 WB, IHC, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 104-124) antibodyCASP4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: 1/16000. Western blot: 0.3-1.0 μg/mL. Approx 40 kDa band observed in Human Heart lysates(calculated MW of 43.0 kDa according to NP_001216.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
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- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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别名
- Caspase-4
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背景
- Caspase 4 is a 377 amino acid protein (43 kDa) that belongs to the Ced3/ICE family of cystein proteases. Caspase 4 is an "upstream" caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have 67 % homology to mature Caspase 1 over the equivalent coding sequences. Caspase 4 is capable of cleaving itself and the p30 Caspase 1 precursor, and of inducing apoptosis in transfected insect or COS cells. In high concentrations, it can also cleave the nuclear DNA enzyme PARP but the biological relevance of this cleavage is unclear. Caspase 4 mRNA is found in most tissues examined with the exception of the brain. Highest expression is found in spleen and lung, with moderate expression in heart and liver. Low expression is observed with skeletal muscle, kidney, and testis.Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
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基因ID
- 837, 9606
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UniProt
- P49662
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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