Axin 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for Axin 抗体 (C-Term) (ABIN372934)
抗原
See all Axin (AXIN1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
序列
- c-FEEKIIGKVE KVD
-
特异性
- This antibody recognizes Axin 1 (AXIN1).
-
交叉反应 （详细）
-
Species reactivity (expected):Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography.
-
免疫原
- Synthetic peptide from C-terminus of Human AXIN1.
-
亚型
- IgG
-
-
anti-Axin 1 (AXIN1) (AA 546-752) antibody
AXIN1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4E9F1 unconjugated
anti-Axin 1 (AXIN1) (AA 618-827) antibodyAXIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 643-740) antibodyAXIN1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Axin 1 (AXIN1) (AA 546-752) antibodyAXIN1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4F10G1 unconjugated
anti-Axin 1 (AXIN1) (AA 653-862) antibodyAXIN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 710-738) antibodyAXIN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 761-862) antibodyAXIN1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 654-863) antibodyAXIN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 1-351) antibodyAXIN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 418-707) antibodyAXIN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA: 1/28000. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Tris-Saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
-
-
- Axin (AXIN1) (Axin 1 (AXIN1))
-
别名
- Axin-1
-
背景
- Axin-1 (Axis inhibition protein 1) and Axin-2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin-1 interacts with APC, GSK3-beta, Dvl and beta-Catenin and promotes the GSK3-beta-mediated phosphorylation and subsequent degradation of beta-Catenin (1,2). Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling (3,4). In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) (5). Axin2 (also known as Conductin or Axil) can functionally substitute Axin1 in mice (6). Axin-2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop (7-9).Synonyms: AXIN, AXIN1, Axis inhibition protein 1
-
基因ID
- 8312
-
NCBI登录号
- NP_003493
-
UniProt
- O15169
-
途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
-
