JAG1 抗体 (AA 110-125)
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Quick Overview for JAG1 抗体 (AA 110-125) (ABIN372790)
抗原
See all JAG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 110-125
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特异性
- Recognizes Human Jagged-1 (JAG1).
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交叉反应 （详细）
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Species reactivity (expected):Chimpanzee, Rat and Mouse (100 % homology).Canine (81 %) and Xenopus laevis (85 %).
Species reactivity (tested):Human. -
纯化方法
- Protein A Chromatography.
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免疫原
- Synthetic peptide corresponding to aa 110-125 of Human Jagged-1 protein.
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亚型
- IgG
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anti-Jagged 1 (JAG1) (N-Term) antibody
JAG1 适用: 人, 小鼠 WB, IHC, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (Internal Region) antibodyJAG1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 47-212) antibodyJAG1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7C7H2 unconjugated
anti-Jagged 1 (JAG1) (AA 47-212) antibodyJAG1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6A9B2 unconjugated
anti-Jagged 1 (JAG1) (AA 836-1047) antibodyJAG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 809-1046) antibodyJAG1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) antibodyJAG1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal J1G53-3 unconjugated
anti-Jagged 1 (JAG1) (AA 470-834) antibodyJAG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 33-250) antibodyJAG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 826-1084) antibodyJAG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/2500-1/10000. Western Blot: 1/250-1/1000. Detects a band approximately 150 kD in size corresponding toJagged-1 in Mouse liver whole cell lysate and a 70 kD band in Human brain and kidneylysates. Immunocytochemistry. Immunofluorescence: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.53 mg/mL
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缓冲液
- PBS, pH 7.2 containing 0.01 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- JAG1 (Jagged 1 (JAG1))
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别名
- CD339 / JAG1
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背景
- Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome.Synonyms: JAGL1, Jagged-1, hJ1
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基因ID
- 182
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NCBI登录号
- NP_000205
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UniProt
- P78504
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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