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SYN1 抗体

SYN1 适用: 人, 小鼠, 大鼠 WB, IF, IP, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN372716
发货至: 中国
  • 抗原 See all SYN1 抗体
    SYN1 (Synapsin I (SYN1))
    适用
    • 116
    • 94
    • 75
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 122
    • 7
    克隆类型
    • 114
    • 15
    多克隆
    标记
    • 75
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SYN1 antibody is un-conjugated
    应用范围
    • 86
    • 44
    • 31
    • 19
    • 16
    • 13
    • 13
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Specific for the ~78k Synapsin I doublet in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.
    交叉反应 (详细)
    Species reactivity (tested):Human, Mouse and Rat.
    纯化方法
    Affinity Chromatography.
    免疫原
    Native protein purified from bovine brain.
    亚型
    IgG
    Top Product
    Discover our top product SYN1 Primary Antibody
  • 应用备注
    Western blot: 1/1000. Immunoprecipitation: 1 μg per 200 μg lysate. Immunofluorescence: 1/2000 (Frozens Sections). Immunohistochemistry: 1/2000 (Frozens Sections).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore in 50 μL PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.
    缓冲液
    5 mM Ammonium Bicarbonate.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted after reconstitution (in aliquots) at-20 °C.
  • Magupalli, Mochida, Yan, Jiang, Westenbroek, Nairn, Scheuer, Catterall: "Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels." in: The Journal of biological chemistry, Vol. 288, Issue 7, pp. 4637-48, (2013) (PubMed).

    Forman, Trojanowski, Lee: "TDP-43: a novel neurodegenerative proteinopathy." in: Current opinion in neurobiology, Vol. 17, Issue 5, pp. 548-55, (2008) (PubMed).

    Tanabe, Shen, Liu, Campbell, Kuroha, Yamamoto, Engel: "The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription." in: Genes & development, Vol. 21, Issue 21, pp. 2832-44, (2008) (PubMed).

    Haycock, Kumer, Lewis, Vrana, Stockmeier: "A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope." in: Journal of neuroscience methods, Vol. 114, Issue 2, pp. 205-12, (2002) (PubMed).

    Zhu, Klimek, Dilley, Haycock, Stockmeier, Overholser, Meltzer, Ordway: "Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression." in: Biological psychiatry, Vol. 46, Issue 9, pp. 1275-86, (1999) (PubMed).

  • 抗原
    SYN1 (Synapsin I (SYN1))
    别名
    Synapsin-1 (SYN1 产品)
    别名
    SYN1a antibody, SYN1b antibody, SYNI antibody, Syn-1 antibody, SYN I antibody, si:dkey-90n12.3 antibody, synapsin I antibody, synapsin I L homeolog antibody, SYN1 antibody, Syn1 antibody, syn1.L antibody, syn1 antibody
    背景
    Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989, Stone et al., 1994). Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002).Synonyms: Brain protein 4.1, SYN1, Synapsin I
    基因ID
    6853
    NCBI登录号
    NP_008881
    UniProt
    P17600
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