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NMDAR2A 抗体 (N-Term)

GRIN2A 适用: 大鼠, 小鼠, Cow WB, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN372681
发货至: 中国
  • 抗原 See all NMDAR2A (GRIN2A) 抗体
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    抗原表位
    • 43
    • 26
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    • 15
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    N-Term
    适用
    • 141
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    • 10
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    大鼠, 小鼠, Cow
    宿主
    • 146
    • 49
    • 1
    克隆类型
    • 138
    • 58
    多克隆
    标记
    • 64
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    This NMDAR2A antibody is un-conjugated
    应用范围
    • 155
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody recognizes the ~180k NR2A subunit of the NMDA Receptor.
    交叉反应 (详细)
    Species reactivity (expected):Bovine, Canine and Mouse.
    Species reactivity (tested):Rat.
    纯化方法
    Affinity Chromatography.
    免疫原
    Peptide from the N-terminus of the NR2A subunit of rat NMDA Receptor.
    亚型
    IgG
    Top Product
    Discover our top product GRIN2A Primary Antibody
  • 应用备注
    Western blot: 1/1000. Immunohistochemistry: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at-20 °C.
  • 抗原
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    Abstract
    GRIN2A 产品
    别名
    NMDAR2A antibody, nr2a antibody, GRIN2A antibody, EPND antibody, GluN2A antibody, NR2A antibody, glutamate ionotropic receptor NMDA type subunit 2A antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog antibody, glutamate receptor ionotropic, NMDA 2A antibody, glutamate receptor, ionotropic, NMDA2A (epsilon 1) antibody, GRIN2A antibody, grin2a.L antibody, LOC100438553 antibody, Grin2a antibody
    背景
    The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.Synonyms: GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, NMDAR2A, NR2A
    基因ID
    2903
    NCBI登录号
    NP_000824
    UniProt
    Q12879
    途径
    Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
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