ALOX5 抗体 (pSer523)
-
- 抗原 See all ALOX5 抗体
- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
-
抗原表位
- pSer523
-
适用
- 人, 大鼠, 灵长类
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This ALOX5 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 特异性
- Recognizes the ~80k 5-LO phosphorylated at Ser523 in Western blots.
- 交叉反应 （详细）
-
Species reactivity (expected):non-Human Primates.
Species reactivity (tested):Human and Rat. - 纯化方法
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- 免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser523 of human 5-Lipoxygenase (5-LO).
- 亚型
- IgG
- Top Product
- Discover our top product ALOX5 Primary Antibody
-
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 461-671) antibody
ALOX5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 1-674) antibodyALOX5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 1-300) antibodyALOX5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) antibodyALOX5 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 120-483) antibodyALOX5 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 601-674) antibodyALOX5 适用: 人, 大鼠, 小鼠 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (C-Term) antibodyALOX5 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 461-671) antibodyALOX5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D10 unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 2-149) antibodyALOX5 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) antibodyALOX5 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
-
- 抗原
- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
- 别名
- ALOX5 / LOG5 (ALOX5 产品)
- 别名
- 5-LO antibody, 5-LOX antibody, 5LPG antibody, LOG5 antibody, 5LO antibody, 5LX antibody, AI850497 antibody, F730011J02 antibody, LOX5A antibody, si:dkey-194n13.2 antibody, lox5 antibody, arachidonate 5-lipoxygenase antibody, arachidonate 5-lipoxygenase a antibody, Arachidonate 5-lipoxygenase antibody, ALOX5 antibody, Alox5 antibody, alox5a antibody, AFUA_4G02770 antibody, AOR_1_1362014 antibody, lox5 antibody
- 背景
- The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994), fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO is thus likely to provide a valuable tool for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis and atherosclerosis.Synonyms: 5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase
- 基因ID
- 240
- NCBI登录号
- NP_000689
- UniProt
- P09917
-
