p300 抗体 (AA 1572-2371)
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- 抗原 See all p300 (EP300) 抗体
- p300 (EP300) (E1A Binding Protein P300 (EP300))
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抗原表位
- AA 1572-2371
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适用
- 人, 小鼠, 大鼠, 猴, Mink
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This p300 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Reacts with human p300 protein (residues 1868-1921)
- 交叉反应
- 小鼠
- 交叉反应 (详细)
- Cross reacts with proteins from mouse, rat, monkey and mink.
- 纯化方法
- Purified (protein A)
- 免疫原
- Fusion protein containing residues 1572-2371 of human p300
- 克隆位点
- RW128
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product EP300 Primary Antibody
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- 应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:10-1:2000, IP1:10-1:500, WB1:250-1:500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.4, Sodium azide 0.1 %
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C/-80 °C
- 储存方法
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
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- 抗原
- p300 (EP300) (E1A Binding Protein P300 (EP300))
- 别名
- p300 (EP300 产品)
- 背景
- Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- 基因ID
- 2033
- UniProt
- Q09472
- 途径
- p53 Pathway, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size
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