p300 抗体 (AA 1572-2371)
Quick Overview for p300 抗体 (AA 1572-2371) (ABIN363282)
抗原
See all p300 (EP300) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1572-2371
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特异性
- Reacts with human p300 protein (residues 1868-1921)
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交叉反应
- 小鼠
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交叉反应 (详细)
- Cross reacts with proteins from mouse, rat, monkey and mink.
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纯化方法
- Purified (protein A)
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免疫原
- Fusion protein containing residues 1572-2371 of human p300
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亚型
- IgG1 kappa
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:10-1:2000, IP1:10-1:500, WB1:250-1:500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, Sodium azide 0.1 %
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C/-80 °C
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储存方法
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
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- p300 (EP300) (E1A Binding Protein P300 (EP300))
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别名
- p300
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背景
- Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
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基因ID
- 2033
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UniProt
- Q09472
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途径
- p53 Pathway, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size
抗原
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