This anti-Integrin beta 3 antibody is a 兔 多克隆 antibody detecting Integrin beta 3 in WB. Suitable for 人 和 小鼠. This Primary Antibody has been cited in 1 publication.
The antibody detects endogenous level of total Integrin b3 protein.
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatographyusing epitope-specific immunogen.
免疫原
Peptide sequence around AA 783-787 (I-T-Y-R-G) derived from Human Integrin B3, ITGB3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C/-20 °C
储存方法
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Wang, Bi, Ampah, Zhang, Li, Jiao, Wang, Ba, Zeng: "Lipid raft regulates the initial spreading of melanoma A375 cells by modulating ?1 integrin clustering." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 8, pp. 1679-89, (2013) (PubMed).
抗原
Integrin beta 3 (ITGB3)
别名
Integrin beta3
背景
The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit