FAK 抗体 (pTyr577)
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北京 101111
Quick Overview for FAK 抗体 (pTyr577) (ABIN362476)
抗原
See all FAK (PTK2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr577
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特异性
- The antibody detects endogenous level of FAK only when phosphorylated at tyrosine 576/577.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
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免疫原
- Peptide sequence around phosphorylation site of pTyr 576, pTyr577 (S-T-Y (p) -Y (p) -K-A) derived from Human FAK. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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亚型
- IgG
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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 700-800) antibody
PTK2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr397) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 798-1041) antibodyPTK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 355-490) antibodyPTK2 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr576) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 396-423) antibodyPTK2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20775 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 1-680) antibodyPTK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (C-Term) antibodyPTK2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr861) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) antibodyPTK2 适用: 人, 小鼠 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 10H7 unconjugated
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应用备注
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Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Luteolin reduces the invasive potential of malignant melanoma cells by targeting ?3 integrin and the epithelial-mesenchymal transition." in: Acta pharmacologica Sinica, Vol. 33, Issue 10, pp. 1325-31, (2012) (PubMed).
: "Surface characterization and cytocompatibility of three chitosan/polycation composite membranes for guided bone regeneration." in: Journal of biomaterials applications, Vol. 24, Issue 3, pp. 209-29, (2009) (PubMed).
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- FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
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别名
- FAK
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背景
- Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
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分子量
- 125 kDa
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NCBI登录号
- NP_005598
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UniProt
- Q05397
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途径
- Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
抗原
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