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MAPK14 抗体 (pTyr182)

Cited in 3+ publications. The 兔多克隆 anti-MAPK14 antibody (ABIN362313) specifically detects MAPK14 in WB 和 IHC. The antibody is reactive with 人, 小鼠和大鼠 samples.

(3 references)

产品编号 ABIN362313

发货至: 中国

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Quick Overview for MAPK14 抗体 (pTyr182) (ABIN362313)

抗原

See all MAPK14 抗体

MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This MAPK14 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product MAPK14 Primary Antibody

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pTyr182

特异性

The antibody detects endogenous level of P38MAPK only when phosphorylated at tyrosine 182.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

免疫原

Peptide sequence around phosphorylation site of pTyr182 (T-G-Y (p) -V-A) derived from Human P38 MAPK. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

亚型

IgG
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody
MAPK14 适用: 人, 小鼠, 大鼠, 小鸡, 山羊 WB, ELISA, FACS, IHC (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 299-360) antibody
MAPK14 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8G4D11 unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 141-240) antibody
MAPK14 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 19-279) antibody
MAPK14 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 260-360) antibody
MAPK14 适用: 人 WB, ELISA, IP, IHC (p), PLA 宿主: 小鼠 Monoclonal 3D5 unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 299-360) antibody
MAPK14 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 10B11C8 unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 295-324), (C-Term) antibody
MAPK14 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB2723 unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 1-360) antibody
MAPK14 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (C-Term) antibody
MAPK14 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 14 (MAPK14) antibody
MAPK14 适用: 人, 小鼠, 大鼠, Pig WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Su, Gu, Wang, Wang: "Lidocaine attenuates proinflammatory cytokine production induced by extracellular adenosine triphosphate in cultured rat microglia." in: Anesthesia and analgesia, Vol. 111, Issue 3, pp. 768-74, (2010) (PubMed).

Mashima, Sato, Sugimoto, Tsuruo, Seimiya: "Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions." in: Oncogene, Vol. 28, Issue 1, pp. 9-19, (2009) (PubMed).

Chen, Song, Zhou, Tong, Li, Fu, Guo, Dong, He, Qiao, Zhan, Li: "Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway." in: Oncogene, Vol. 28, Issue 4, pp. 599-609, (2009) (PubMed).
抗原

MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

别名

P38 MAPK

背景

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

分子量

43 kDa

UniProt

Q16539

途径

MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins