TAO Kinase 2 抗体 (pSer181)
Quick Overview for TAO Kinase 2 抗体 (pSer181) (ABIN361519)
抗原
See all TAO Kinase 2 (TAOK2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer181
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特异性
- Specific for the ~120k TAO2 phosphorylated at Ser181 in Western blots. Immunolabeling is completely eliminated by treatment with phosphatase.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- canine, finch, Xenopus, zebrafish
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纯化方法
- Antigen Affinity Purified from Pooled Serum
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免疫原
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH
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anti-TAO Kinase 2 (TAOK2) (AA 831-930) antibody
TAOK2 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 831-930) antibodyTAOK2 适用: 人 ELISA, WB, IF, PLA 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 719-880) antibodyTAOK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 2 (TAOK2) (pSer181) antibodyTAOK2 适用: 人, 小鼠, 大鼠, 犬, 非洲爪蟾 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 610-730) antibodyTAOK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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储存条件
- -20 °C
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- TAO Kinase 2 (TAOK2)
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别名
- TAOK2
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背景
- In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999, Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain. Anti-Phospho Ser181 TAO2 Western blot of rat cortex lysate showing specific immunolabeling of the ~120k TAO2 phosphorylated at Ser181 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Ser181 TAO2 antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
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分子量
- '120 kDa
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基因ID
- 9344
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UniProt
- Q9UL54
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途径
- Cell-Cell Junction Organization
抗原
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