GLRA1 抗体 (N-Term)
Quick Overview for GLRA1 抗体 (N-Term) (ABIN361432)
抗原
See all GLRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- Specific for the ~48k a1- and a2-subunits of the glycine receptor in Western blots of rat spinal cord and brain stem and in cell extracts. Immunolabeling blocked by preadsorption of antibody with the peptide immunogen. Does not recognize other glycine receptor subunits.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antigen Affinity Purified from Pooled Serum
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免疫原
- Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
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anti-Glycine Receptor, alpha 1 (GLRA1) (AA 23-113) antibody
GLRA1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 121-220) antibodyGLRA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E6 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 29-154) antibodyGLRA1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7F8E2 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) antibodyGLRA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Internal Region) antibodyVerified GLRA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 121-220) antibodyGLRA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D9 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Internal Region) antibodyGLRA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) antibodyGLRA1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 1-449) antibodyGLRA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Middle Region) antibodyGLRA1 适用: 人, 大鼠, 小鼠, 犬, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- lyophilized
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储存条件
- -20 °C
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- GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
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别名
- GLRA1
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背景
- Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001, Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002). Anti-Glycine Receptor Western blot of rat spinal cord showing specific immunolabeling of the ~48k (1- and (2-subunits of the glycine receptor. The labeling was absent from a rat hippocampal (hipp) lysate as the glycine receptor is not expressed in the hippocampus.
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分子量
- '48 kDa
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基因ID
- 25674
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UniProt
- P07727
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途径
- Synaptic Membrane
抗原
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