TIM3 抗体
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北京 101111
Quick Overview for TIM3 抗体 (ABIN360940)
抗原
See all TIM3 (TIM 3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects of TIM-3. It does not cross-react with Mouse TIM-1 and TIM-2.
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纯化方法
- Protein A/G Affinity Chromatography
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免疫原
- Purified Mouse recombinant TIM-3
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亚型
- IgG2
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.
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缓冲液
- PBS without preservatives or stabilizers
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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别名
- TIMD3 / HAVCR2
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物质类
- Virus
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背景
- TIM-3 has been identified as a Th1 specific marker initially due to expression on activated and polarized Th1 cells and absence on naive T cells. It has also been found on CD8+ T cells, Th17, Tregs , monocytes and dendritic cells. As a transmemebrane protein, TIM-3 is also referred to as 'T cell immunoglobulin and mucin-like domain containing protein -3.' Enhanced surface expression on CD4+ and CD8+ cells in the CNS are indicative of disease in EAE, murine models of MS. TIM-3 mediated down regulation of Th1 immune responses and induction of immune tolerance illustrate a potential key role for TIM-3 in immunoregulation.Synonyms: HAVCR-2, Hepatitis A virus cellular receptor 2, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3
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基因ID
- 171285
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NCBI登录号
- NP_599011
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UniProt
- Q8VIM0
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途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
抗原
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