TIM-3 has been identified as a Th1 specific marker initially due to expression on activated and polarized Th1 cells and absence on naive T cells. It has also been found on CD8+ T cells, Th17, Tregs , monocytes and dendritic cells. As a transmemebrane protein, TIM-3 is also referred to as 'T cell immunoglobulin and mucin-like domain containing protein -3.' Enhanced surface expression on CD4+ and CD8+ cells in the CNS are indicative of disease in EAE, murine models of MS. TIM-3 mediated down regulation of Th1 immune responses and induction of immune tolerance illustrate a potential key role for TIM-3 in immunoregulation.Synonyms: HAVCR-2, Hepatitis A virus cellular receptor 2, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3