IL-6 Receptor 抗体 (Extracellular Domain)
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- 抗原 See all IL-6 Receptor (IL6R) 抗体
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
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抗原表位
- Extracellular Domain
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This IL-6 Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody detects Mouse IL-6R. Other species not tested.
- 纯化方法
- Protein A/G affinity chromatography
- 免疫原
- Recombinant protein of IL-6R extracellular domain.
- 克隆位点
- 14F33
- 亚型
- IgG2
- Top Product
- Discover our top product IL6R Primary Antibody
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anti-Interleukin 6 Receptor (IL6R) antibody
IL6R 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 20-320) antibodyIL6R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 216-356) antibodyIL6R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) antibodyIL6R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 1-468) antibodyIL6R 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 205-347) antibodyIL6R 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 385-462) antibodyIL6R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 1-468) antibodyIL6R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 21-120) antibodyIL6R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 21-120) antibodyIL6R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E11 unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 溶解方式
- Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.
- 缓冲液
- PBS, None
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- 别名
- CD126 / IL6R (IL6R 产品)
- 别名
- IL6R antibody, il-6ra antibody, CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, IL6R1 antibody, Il6ra antibody, IL-6Ralpha antibody, IL-6R antibody, Il6r antibody, interleukin 6 receptor antibody, interleukin 6 receptor, alpha antibody, IL6R antibody, il6r antibody, Il6r antibody, Il6ra antibody
- 背景
- IL6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL6 binding receptor protein (IL6R) and a 130 kDa signal transducing protein consisting of a 19 amino acid residue signal peptide (gp130). Human IL6R is a 468 amino acid residue type I membrane protein consisting of a 19 amino acid residue signal peptide, a 339 residue extracellular region, a 28 residue transmembrane region and an 82 residue cytoplasmic region. The ectodomain of IL6R is made up of an immunoglobulin like domain and a cytokine receptor superfamily domain. A naturally occurring soluble form of the IL6R, which binds IL6 and which mediates IL6 signaling through interaction with gp130, is identified in the urine of healthy adult humans. It has also been detected in human and mouse serum as well as in the conditioned medium of various cells including human peripheral blood mononuclear cells, and several T cell or granulocyte/macrophage cell lines. Increased expression of the c-fos and c-myc protooncogenes have been linked to IL6 receptor activation.Synonyms: IL-6R 1, IL-6R-alpha, IL6 Receptor alpha, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80
- 基因ID
- 16194
- NCBI登录号
- NP_034689
- UniProt
- P22272
- 途径
- JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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