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Lamin B2 抗体

LMNB2 适用: 人, 小鼠, 斑马鱼, 非洲爪蟾, Hamster, Pig WB, FACS, IHC (fro) 宿主: 小鼠 Monoclonal LN43 unconjugated
产品编号 ABIN360851
发货至: 中国
  • 抗原 See all Lamin B2 (LMNB2) 抗体
    Lamin B2 (LMNB2)
    适用
    • 54
    • 40
    • 19
    • 10
    • 5
    • 5
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    • 2
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    人, 小鼠, 斑马鱼, 非洲爪蟾, Hamster, Pig
    宿主
    • 52
    • 17
    小鼠
    克隆类型
    • 49
    • 20
    单克隆
    标记
    • 38
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
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    This Lamin B2 antibody is un-conjugated
    应用范围
    • 50
    • 15
    • 14
    • 14
    • 13
    • 13
    • 12
    • 8
    • 7
    • 7
    • 7
    • 2
    • 1
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    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Reacts with an epitope located in the C-terminal part of Lamin B2.
    纯化方法
    Purified
    免疫原
    Detergent insoluble fraction of potoroo cell line PtK1.
    克隆位点
    LN43
    亚型
    IgG1
    Top Product
    Discover our top product LMNB2 Primary Antibody
  • 应用备注
    Suitable for Immunocytochemistry on Frozen Sections, Immunoblotting and FlowCytometry. Recommended Dilutions: 1/100-1/200 for Flow cytometry and for Immunohistochemistry with avidin-biotinylatedhorseradish peroxidase complex (ABC) as detection reagent.1/100-1/1000 for Immunoblotting applications.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS with 0.09 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store lyophilized at 2 - 8 °C and reconstituted at -20 °C.
  • 抗原
    Lamin B2 (LMNB2)
    别名
    Lamin-B2 (LMNB2) (LMNB2 产品)
    别名
    lmnb2-a antibody, LMNB2 antibody, lmn2 antibody, lamb2 antibody, Lamin-L(II) antibody, LOC100136040 antibody, im:7142331 antibody, lamin antibody, wu:fb94e05 antibody, wu:fb95e12 antibody, wu:fc15d06 antibody, wu:fc49h03 antibody, lamin-b2 antibody, lmnb2 antibody, LAMB2 antibody, LMN2 antibody, RGD1563803 antibody, lamin B2 S homeolog antibody, lamin B2 antibody, lamin B2 L homeolog antibody, lmnb2.S antibody, LMNB2 antibody, lmnb2 antibody, lmnb2.L antibody, Lmnb2 antibody
    背景
    An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of a-helices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organised into loops, which are attached to the nuclear matrix. This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins.Synonyms: LMN2, LMNB, LMNB-2, LMNB2, Lamin-B2, Nuclear Envelope Marker
    基因ID
    84823
    NCBI登录号
    NP_116126
    UniProt
    Q03252
    途径
    Apoptosis, Caspase Cascade in Apoptosis
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