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EIF2AK2 抗体 (N-Term)

Name: EIF2AK2 抗体 (N-Term)
SKU: ABIN360663
Availability: OutOfStock

The 兔多克隆 anti-EIF2AK2 antibody (ABIN360663) specifically detects EIF2AK2 in WB, IHC (p) 和 EIA. The antibody is reactive with 人和小鼠 samples.

Image no. 2 for anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (N-Term) antibody (ABIN360663) (EIF2AK2 抗体 (N-Term))

Image no. 1 for anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (N-Term) antibody (ABIN360663) (EIF2AK2 抗体 (N-Term))

2 images

产品编号 ABIN360663

发货至: 中国

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中国
北京 101111

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Quick Overview for EIF2AK2 抗体 (N-Term) (ABIN360663)

抗原

See all EIF2AK2 抗体

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This EIF2AK2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Discover our top product EIF2AK2 Primary Antibody

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N-Term

特异性

This antibody reacts to PRKR.

纯化方法

Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

免疫原

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PRKR.

亚型

Ig Fraction
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D11 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 329-551) antibody
EIF2AK2 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6H3A10 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 224-502) antibody
EIF2AK2 适用: 人 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) antibody
KD Validated EIF2AK2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB7125 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C2 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 519-550) antibody
EIF2AK2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 11-42) antibody
EIF2AK2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr446) antibody
EIF2AK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr451) antibody
EIF2AK2 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Flow cytometry.

限制

仅限研究用
状态

Liquid

浓度

0.25 mg/mL

缓冲液

PBS with 0.09 % (W/V) sodium azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
抗原

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

别名

EIF2AK2 / PKR

背景

Interferon-induced, double-stranded RNA-activated protein kinase (PRKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PRKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. Human gamma-interferon (IFNG) mRNA exploits localized activation of PRKR in the cell to regulate its own translation. IFNG mRNA activates PRKR through a pseudoknot in its 5-prime untranslated region. The HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PRKR and the translation initiation factor EIF2-alpha, a target of PRKR. E2 inhibits the kinase activity of PRKR and blocks its inhibitory effect on protein synthesis and cell growth, which provides one mechanism by which HCV may circumvent the antiviral effect of interferon. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, also activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PRKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system. Roles for PRKR activation in Huntington disease and Fanconi anemia have also been suggested.Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 2, Interferon-induced double-stranded RNA-activated protein kinase, PRKR, Protein kinase RNA-activated, eIF-2A protein kinase 2, p68 kinase

基因ID

5610

NCBI登录号

NP_001129123

UniProt

P19525

途径

DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C