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PAK3 抗体 (Middle Region)

The 兔 多克隆 anti-PAK3 antibody is suitable to detect PAK3 in samples from 人. It has been validated for WB, IHC (p) 和 EIA.
产品编号 ABIN360320
发货至: 中国
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Quick Overview for PAK3 抗体 (Middle Region) (ABIN360320)

抗原

See all PAK3 抗体
PAK3

适用

  • 85
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  • 30
  • 3

宿主

  • 80
  • 5
  • 2

克隆类型

  • 70
  • 18
多克隆

标记

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This PAK3 antibody is un-conjugated

应用范围

  • 68
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

    • 17
    • 8
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    Middle Region

    特异性

    This antibody reacts to PAK3.

    纯化方法

    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

    免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human PAK3.

    亚型

    Ig Fraction
  • 应用备注

    ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS with 0.09 % (W/V) sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原

    PAK3

    别名

    PAK3

    背景

    PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30). The protein structure contains 1 CRIB domain.Synonyms: Beta-PAK, OPHN3, Oligophrenin-3, PAK 3, PAK beta, PAK-3, Serine/threonine-protein kinase PAK 3, p21-activated kinase 3

    基因ID

    5063, 9606

    UniProt

    O75914
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