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ASK1 抗体 (Ser1033)

MAP3K5 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN360294
发货至: 中国
  • 抗原 See all ASK1 (MAP3K5) 抗体
    ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
    抗原表位
    • 26
    • 26
    • 18
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    • 12
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    • 9
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    • 5
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    Ser1033
    适用
    • 182
    • 99
    • 57
    • 18
    • 15
    • 8
    宿主
    • 190
    • 8
    克隆类型
    • 170
    • 28
    多克隆
    标记
    • 80
    • 12
    • 12
    • 9
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    • 8
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    This ASK1 antibody is un-conjugated
    应用范围
    • 157
    • 58
    • 39
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    • 38
    • 29
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    • 11
    • 11
    • 6
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to ASK1 (MEKK5/MAP3K5).
    纯化方法
    Affinity chromatography on Protein A
    免疫原
    KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S83 of human MAP3K5.
    亚型
    Ig Fraction
    Top Product
    Discover our top product MAP3K5 Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
    别名
    MEKK5 / ASK1 (MAP3K5 产品)
    别名
    ASK1 antibody, MAPKKK5 antibody, MEKK5 antibody, mitogen-activated protein kinase kinase kinase 5 antibody, MUD21.11 antibody, MUD21_11 antibody, 7420452D20Rik antibody, ASK antibody, Mekk5 antibody, Ask1 antibody, RGD1306565 antibody, mitogen-activated protein kinase kinase kinase 5 antibody, MAP3K5 antibody, MAPKKK5 antibody, Map3k5 antibody, map3k5 antibody
    背景
    Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.Synonyms: Apoptosis signal-regulating kinase 1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, Mitogen-activated protein kinase kinase kinase 5
    基因ID
    4217, 9606
    UniProt
    Q99683
    途径
    MAPK Pathway, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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